I know what I think will happen, but I'm not saying it. I just can't let my hopes get up too much for this one. I've been burned too often. I'm going to try to go into it expecting to lose and hopefully be pleasantly surprised. I'll give my takes though.
For OU to win, they will want it to be high scoring. They should attack our weak secondary and then use that to set up the run. Specifically with Gabriel scrambling. They are not stopping Gordon, but if they get up on us early and force us to play from behind that could cause us to move away from the run and rely on a middle class passing game against a very good secondary. That would spell trouble for us.
The worst thing OU can do IMHO is sell out to stop the run. We've seen what happens with that for the last few weeks. Cinci has most likely a better run defense than OU and they still got hammered by Gordon and our O-Line. OU should instead try to manage our running game and shut down our passing to make us one dimensional. Then when we get into those 3rd and long situations we are screwed.
On the OSU side, we need to figure out a way for our defense to manage their passing attack and keep them no higher than moderate scoring (mid-30s). We can't let them get up on us by two TDs plus. I don't think we will do well playing from behind. That is easily my biggest concern with this game.
However, our weakness is also our strength. If we are ahead by 2+ TDs I don't think they will be able to recover because our ground game will be grinding the crap out of them and eating up that clock. Similarly, if this is a close game (especially if it is low scoring) going into the 4th I think OU is in trouble. Ollie and our O-Line will chew them up and make them pay. Our offense seems born to finish games.