Company brings back once extinct predator

Because someone only watched the first half of Jurassic Park
Jurassic Park Ian Malcom GIF
 
Wouldnt say it wasn't used, that implies purely selective breeding to get certaintraits accentuated over generations. You are correct though, it's not like they fully replaced grey wolf DNA with dire wolf DNA. But they used it as a guide to adjust grey wolf DNA to match certain genes they thought were important.

My question is how do you get a diverse enough gene pool to have subsequent generations without pure inbreeding? You'd have to make a bunch of them, right?

"Shapiro and the researchers at Colossal contacted museums and laboratories with dire wolf specimens and got access to a tooth thought to be about 13,000 years old, found in Ohio, and a 72,000-year-old skull from Idaho. Inside the skull is the petrous, or inner ear bone, which is a good source of well-preserved DNA, Shapiro said.

From those two specimens, Shapiro and the team at Colossal recovered enough DNA to create two dire wolf genomes to compare with other canid species including coyotes, jackals, dholes and, of course, other wolves, Shapiro said. Using the genetic data, researchers could confirm the gray wolf as the closest living relative of the dire wolf – they share 99.5% of their DNA code.

Next, the Colossal researchers edited the gray wolf genome in 20 sites over 14 genes to express specific traits of dire wolves including a light-colored coat, hair length, coat patterning, along with body size and musculature.

Fertilized dire wolf eggs were implanted into and born by surrogate dog mothers. Two litters have led to a pair of male dire wolves, Romulus and Remus, now six months old, and a female, Khaleesi (named after the "Game of Thrones" character), born in January. These newcomers are not 100% exactly the same dire wolf that roamed the earth ages ago, but look as genetically close as cutting-edge technology could get."

 
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