I assumed China's change was the one child policy's affect on the male/female ratio of the population. More males=taller average
American Healthcare continues to go backward
- Thread starter steross
- Start date
Decreasing poverty also. China is pretty wealthy and ability to purchase food makes kids grow.
Polds4OSU
Marshall
As near as I can tell, this garbage is still technically "on the market", no action has been taken by the FDA since approval. However, it appears to be no longer available from the manufacturer. It comes off patent in 2031 so you can bet your bottom dollars generics will hit the market, despite the fact that no one should actually use this.
Tramadol and celecoxib (commonly branded as Seglentis) are combined to treat acute, moderate-to-severe pain, offering improved relief over either drug alone by combining an NSAID (celecoxib) with an opioid (tramadol). This combination allows lower doses of each component, reducing overall opioid exposure, though it carries risks of addiction, misuse, severe cardiovascular events, and gastrointestinal bleeding. [1, 2, 3, 4, 5]
Key Aspects of the Combination:
AI can make mistakes, so double-check responses
[1] https://www.mayoclinic.org/drugs-su...-tramadol-oral-route/description/drg-20524738
[2] https://www.drugs.com/mtm/celecoxib-and-tramadol.html
[3] https://my.clevelandclinic.org/health/drugs/23625-celecoxib-tramadol-tablets
[4] https://www.empr.com/home/news/celecoxib-tramadol-combo-tablet-approved-for-acute-pain/
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC10084286/
[6] https://www.tandfonline.com/doi/full/10.1080/03007995.2023.2276118
[7] https://pubmed.ncbi.nlm.nih.gov/35686380/
[8] https://pmc.ncbi.nlm.nih.gov/articles/PMC9826359/
[9] https://reference.medscape.com/drug/seglentis-celecoxib-tramadol-4000087
[10] https://www.drugs.com/drug-interactions/celebrex-with-tramadol-560-284-2221-0.html
[11] https://www.drugs.com/drug-interactions/celecoxib-tramadol.html
Tramadol and celecoxib (commonly branded as Seglentis) are combined to treat acute, moderate-to-severe pain, offering improved relief over either drug alone by combining an NSAID (celecoxib) with an opioid (tramadol). This combination allows lower doses of each component, reducing overall opioid exposure, though it carries risks of addiction, misuse, severe cardiovascular events, and gastrointestinal bleeding. [1, 2, 3, 4, 5]
Key Aspects of the Combination:
- Uses: Used for short-term management of acute pain that requires an opioid and for which alternative treatments are inadequate.
- Mechanism: The combo acts on the central nervous system (tramadol) to block pain signals while reducing inflammation (celecoxib).
- Dosage: Common dosing involves 112 mg of celecoxib/88 mg of tramadol (often as 100 mg tablets, 2 tablets per dose) every 12 hours as needed.
- Side Effects: Potential side effects include nausea, vomiting, dizziness, headache, somnolence, and constipation.
- Serious Risks: Increased risk of fatal heart attack, stroke, and stomach or intestinal bleeding.
- Warnings: Contraindicated shortly after heart bypass surgery (CABG) and in patients with known hypersensitivity to NSAIDs or opioids. [1, 2, 3, 4, 5, 6]
- Seglentis: An FDA-approved 56mg celecoxib/44mg tramadol immediate-release tablet.
- Co-crystal (CTC): Clinical trials suggest that a 1:1 molecular co-crystal (CTC) improves the pharmacokinetic profile of both drugs. [4, 5, 6, 7, 8]
- Addiction & Dependence: Although intended for short-term use, this combination is a Schedule IV controlled substance due to the tramadol component, which can lead to dependence.
- Drug Interactions: Over 1,000 interactions are known, including with other serotonergic medications which can cause serotonin syndrome.
- Older Adults: Increased risk of serious GI events, particularly in elderly or debilitated patients. [4, 5, 9, 10, 11]
AI can make mistakes, so double-check responses
[1] https://www.mayoclinic.org/drugs-su...-tramadol-oral-route/description/drg-20524738
[2] https://www.drugs.com/mtm/celecoxib-and-tramadol.html
[3] https://my.clevelandclinic.org/health/drugs/23625-celecoxib-tramadol-tablets
[4] https://www.empr.com/home/news/celecoxib-tramadol-combo-tablet-approved-for-acute-pain/
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC10084286/
[6] https://www.tandfonline.com/doi/full/10.1080/03007995.2023.2276118
[7] https://pubmed.ncbi.nlm.nih.gov/35686380/
[8] https://pmc.ncbi.nlm.nih.gov/articles/PMC9826359/
[9] https://reference.medscape.com/drug/seglentis-celecoxib-tramadol-4000087
[10] https://www.drugs.com/drug-interactions/celebrex-with-tramadol-560-284-2221-0.html
[11] https://www.drugs.com/drug-interactions/celecoxib-tramadol.html
So we have two drugs with very significant issues, and widely available and inexpensive alternatives. Hey, maybe if we combine them!
Sort of like thinking taking a speedball will get you addicted to the heroin slower and the cocaine will be less likely to cause arrhythmias.
I defend pharma all the time. But this was indefensible, a crass money grab, combining the worst nsaid with the worst opioid, both in sub therapeutic doses, just so they can slap a brand name on it and sell it for more.
No one anywhere should be prescribed this s**t. It’s awful. If it has been discontinued the world is better for it. The only problem is if it is still FDA approved then when it is off patent there inevitably will be generics.
Similar threads
